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We focus on the evolution and epidemiology of emerging viruses at the animal-human interface. Major achievements in the past include the development of affordable tests for HIV, hepatitis C virus and yellow fever virus for Brazilian public laboratories, the uncovering of the zoonotic origins of major human viruses like hepatitis A and B virus, and the elucidation of central aspects of the epidemiology of the Latin American Zika virus outbreak.
Arthropod-borne viruses (arboviruses) infect millions of people annually and are major threats to public health. Fueled by global warming and increasing human mobility, arboviruses and their vectors spread rapidly. Arboviruses of major importance in recent years are the Zika virus, the Chikungunya virus and the Yellow fever virus, which all caused large outbreaks in Latin America. In close collaboration with Brazilian partners, we conduct epidemiological studies to gain insights into the ecology, the evolution and the pathogenesis of arboviruses. We are particularly interested in why Zika virus causes congenital malformations in some, but not all pregnant women infected. Our research includes the examination of potential co-factors affecting the disease outcome and the exploration of potential animal reservoirs which could allow Zika to survive in sylvatic transmission cycles in Latin America.
Funding: ZIKAlliance (EU), ZikaStock (Roche), ZIKApath (DZIF)
Arbovirus novel diagnostics
Robust and timely diagnosing of arbovirus infections is fundamental to provide optimal patient care and forms the basis of successful outbreak surveillance and response. Diagnostics of arbovirus infections are hampered by inconclusive symptoms and co-circulation of different arboviruses, often in resource-limited settings. We support diagnostic laboratories by developing innovative tests amenable for resource-limited settings, provide optimized protocols and conduct external quality assessments. We focus on molecular surveillance of Chikungunya virus, molecular diagnostics of Zika virus and broad detection of alphaviruses and flaviviruses.
Funding: Alphanet (BMBF), ArboFusion (BMBF), HONOURs (EU)
Macro-evolutionary patterns of human viruses and their animal homologues
We focus on the evolutionary biology of human-pathogenic viruses originating from animal reservoirs. Recent studies of our group revealed evolutionary origins of major human viruses like hepatitis A virus in marsupials, hedgehogs and bats, all belonging to some of the oldest mammalian orders. Characterization of functional and genomic properties of these highly diversified viruses contributes to understanding their macro-evolutionary patterns to elucidate why and which reservoir-bound viruses have become major human pathogens.
Funding: DZIF, Probing persistence paradigms (HFSP), HONOURs (EU)
- Prof. Alexander N. Lukashev, Chumakov Institute for Encephalitides, Moscow, Russia
- Prof. Eric M. Leroy, Centre International de Recherches Médicales de Franceville (CIRMF), Gabon
- Prof. Roberto Franke, Federal University of Bahia, Salvador, Brazil
- Prof. Eduardo M. Netto, Federal University of Bahia, Salvador, Brazil
- Prof. Dieter Glebe, University of Giessen, Germany
- Prof. Martin Beer, Friedrich-Loeffler-Institut, Greifswald – Insel Riems, Germany
- PD Rainer Ulrich, Friedrich-Loeffler-Institut, Greifswald – Insel Riems, Germany
- Prof. Eike Steinmann, TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hannover, Germany
- Prof. Thomas Pietschmann, TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hannover, Germany
- Prof. Xavier de Lamballerie, Unité de Virus Emergents, Faculté de Médecine, Marseille, France
- PD Thomas Jänisch Universitätsklinikum Heidelberg, Germany
- Dr. Alvaro Aguilar Setién, Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, México D.F., Mexico
- Prof. Thijs Kuiken, Erasmus MC, Rotterdam, The Netherlands
- Prof. Eugenia Corrales Aguilar, Virology-CIET, University of Costa Rica, Costa Rica
A current list of all publications can be found in the pubmed-List.