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Due to the zoonotic nature of many coronaviruses, we are interested in understanding functional differences in which viruses deal with host cell defenses across different host species. By the example of SARS-coronavirus papain-like protease and the MERS-coronavirus accessory proteins 4a and 4b we investigate protein variants from epidemic and reservoir-associated coronavirus strains. We use in-vitro assays and reverse genetic systems to explore the functional diversity of these immune modulating factors.
- MSc Kirstin Mösbauer